Conference Chair: Marshall B. Elam, MD, PhD, University of Tennessee Health Science Center
Vice Chair: Nancy R. Webb, PhD, University of Kentucky

2009 Program Schedule

Thursday, September 24, 2009

7:00 PM: Arrival and Registration

Friday, September 25, 2009

7:00 - 7:50 AM - Registration and Breakfast

7:50 - 8:00 AM - Welcome and Opening - Marshall B. Elam, MD, PhD

Session 1: HDL BIOGENESIS AND METABOLISM
Moderator: Michael C. Phillips, PhD, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine

8:00 - 8:30 AM - Michael C. Phillips, PhD, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine

• ABCA1-mediated Efflux of Cellular Lipids and Formation of Nascent HDL Particles

8:30 - 9:00 AM - John S. Parks, PhD, Wake Forest University

• The Role of Apolipoprotein M in HDL Biogenesis and Heterogeneity

9:00 - 9:30 AM - Henry J. Pownall, PhD, Baylor College of Medicine

• Enhanced Reverse Cholesterol Transport via Disruptive HDL Therapy

9:30 - 9:45 AM - Marcielle de Beer, PhD, University of Kentucky

• Cholesterol Efflux During the Acute Phase Response

9:45 - 10:00 AM - Anisa Jahangiri, PhD, University of Kentucky

• HDL Remodeling During Inflammation

10:00 AM - 10:30 AM - BREAK

Session 2: MACROPHAGE FUNCTION IN METABOLISM
Moderator: Alyssa H. Hasty, PhD, Vanderbilt University

10:30 - 11:00 AM - Preetha Shridas, PhD, University of Kentucky

• Group X Secretory Phospholipase A2 Supresses Liver X Receptor Activation and Enhances Inflammatory Response in Macrophages

11:00 - 11:30 AM - Liza Makowski, PhD, Duke University

• Manipulating Fuel Metabolism with Carnitine Alters Macrophage Inflammatory Potential

11:30 - 12:00 PM - Norbert Leitinger, PhD, University of Virginia

• NF-E2 Related Factor 2 (Nrf2) Controls Macrophage Function and
  Diet-induced Insulin Resistance
  

12:00 - 12:15 PM - Michael J. Puglisi, PhD, Vanderbilt University

• Deficiency of Toll-Like Receptor 4 and its Effects on Inflammation in Adipose Tissue in Response to Diets Rich in Saturated or Monounsaturated Fatty Acids

12:15 - 12:30 - Yanice Mendez-Fernandez, PhD, Vanderbilt University

• FcgRIIB Influences Cardiovascular Disease by Modulating the
  Inflammatory Response of Antigen Presenting Cells
  

12:30 - 3:30 PM - BREAK

3:30 - 5:00 PM POSTER SESSION AND COMPETITION

Winners of 2009 SELRC Outstanding Poster Presentation Awards

First Place Awards: Jenna Betters, PhD and Tam Nguyen

Runner-Up Award: Jingjing Liu

5:00 - 6:30 PM POSTER SESSION RECEPTION and "LITE BITES"

6:30 PM - 7:30 PM: W. VIRGIL BROWN KEYNOTE ADDRESS

Henry N. Ginsberg, MD
Irving Professor of Medicine and
Director, Irving Institute of Clinical and Translational Research
Columbia University
New York, NY

Do Therapies that Lower Levels of TG-Rich Lipoproteins Reduce the Risk of Cardiovascular Events

Saturday, September 26, 2009

7:00 - 8:00 AM - Breakfast

Session 3: BIOACTIVE LIPIDS
Moderator: W. Scott Argraves, PhD, Medical University of South Carolina

8:00 - 8:30 AM - Kelly M. Argraves, PhD, Medical University of South Carolina

• Sphingosine-1-phosphate receptor signaling in embryonic blood vessel formation

8:30 - 9:00 AM - Menq-Jer Lee, PhD, University of Louisville

• The Yin-Yang Regulation of Vascular Function by Sphingosine-1-Phosphate Signaling

9:00 - 9:30 AM - Chiara Luberto, PhD, Medical University of South Carolina

• Sphingomyelin Synthase in Chronic Myelogenous Leukemia

9:30 - 10:00 AM - Erhard Bieberich, PhD, Medical College of Georgia

• The Bright Side of Ceramide: Novel Function of a Death Lipid in Cell Polarity and Ciliogenesis

10:00 AM - 10:30 AM - BREAK

Session 4: TRIGLYCERIDE-RICH LIPOPROTEINS IN ATHEROSCLEROTIC CV DISEASE
Moderator: Peter W. Wilson, MD, Emory University

10:30 - 11:00 AM - Peter W. Wilson, MD, Emory University

• Role of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

11:00 - 11:30 AM - Henry N. Ginsberg, MD, Columbia University

• Insulin Resistance, Free Fatty Acids, and Triglycerides

11:30 - 12:00 PM - Maria F. Lopes-Virella, MD, PhD, Medical University of South Carolina

• Lipid Particles, Autoantibodies, and Atherosclerosis

12:00 - 12:30 PM - Nhoc-Anh Le, PhD, Emory University

• Fatty Meals and Lipid Oxidation

12:30 - 3:30 PM - BREAK

Session 5: DYSREGULATION OF LIPID METABOLISM IN OBESITY
Moderator: Elizabeth J. Parks, PhD, University of Texas Southwestern Medical Center

3:30 - 4:00 PM - Elizabeth J. Parks, PhD, University of Texas Southwestern Medical Center

• An Extended Time Frame for Lipid Absorption Through the Enterocyte in
  Humans

4:00 - 4:30 PM - Charles M. Mansbach, MD, University of Tennessee Health Sciences Center

• Initiating Events in the Budding of the Pre-chylomicron Transport
  Vesicle

4:30 - 5:00 PM - Ling Li, DVM, PhD, University of Alabama at Birmingham

• Role of Diet-Induced Insulin Resistance in Alzheimer's Disease: Insights from Animal Studies

5:00 - 5:30 PM - Erik R. Eckhardt, PhD, University of Kentucky

• A Novel Effect of Dietary Fat on Inflammation and Immunity: Promotion
  of Absorption and Systemic Dissemination of Microbial and Dietary
  Antigens

5:30 PM - Dinner on your own

 

Sunday, September 27, 2009

7:00 - 8:00 AM - Breakfast

Session 6: PATHOGENESIS OF INSULIN RESISTANCE IN OBESITY AND DIABETES
Moderator: Philip A. Kern, MD, University of Kentucky

8:00 - 8:30 AM - Philip A. Kern, MD, University of Kentucky

• Adipose Tissue Inflammation and Insulin Resistance

8:30 - 9:00 AM - W. Timothy Garvey, MD, University of Alabama at Birmingham

• Adiponectin and Metabolic Syndrome

9:00 - 9:30 AM - Charlotte A. Peterson, PhD, University of Kentucky

• Muscle Inflammation and Insulin Resistance: Does Pain Result in Gain?

9:30 - 10:00 AM - Tina E. Brinkley, PhD, Wake Forest University

• Adipose and Skeletal Muscle Inflammatory Mediators: Association with Physical Function in Older Persons

10:00 AM - 10:30 AM - BREAK

Session 7: MOLECULAR MECHANISMS OF DYSLIPIDEMIA IN OBESITY AND DIABETES
Moderator: Edwards A. Park, PhD, University of Tennessee Health Science Center

10:30 - 11:00 AM - Brad Hillgartner, PhD, West Virginia University

• Fibroblast Growth Factor-19, A Novel Factor the Inhibits Hepatic Fatty Acid Synthesis

11:00 - 11:15 AM - Xiong Deng, PhD, University of Tennessee Health Science Center

• Transcriptional Regulation of SREBP-1c by Insulin

11:15 - 11:30 PM - Chandrahasa R. Yellaturu, PhD, University of Tennessee Health Science Center

• Insulin Enhances Proteolytic Processing of SREBP-1c

11:30 - 12:00 PM - P. Darrell Neufer, PhD, East Carolina University

• Linking Mitochondrial Bioenergetics to Insulin Resistance

12:00 - 12:30 PM - Owen P. McGuinness, PhD, Vanderbilt University

• Challenges to Assessing Insulin Action in the Mouse

12:30 PM: Closing Comments and Adjournment - Marshall B. Elam and Nancy Webb